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Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 200-206 doi: 10.1007/s11684-007-0038-y

Abstract: of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic of type 2

Keywords： palmitate     characteristic     study     plasma     resistance    

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Relationship between reactive oxygen species and sodium-selenite-induced DNA damage in HepG2 cells

ZOU Yunfeng, NIU Piye, GONG Zhiyong, YANG Jin, YUAN Jing, WU Tangchun, CHEN Xuemin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 327-332 doi: 10.1007/s11684-007-0063-x

Abstract: study, we investigated the relationship between ROS and the levels of DNA damage induced by selenite in HepG2cells.After HepG2 cells were treated with selenite, there was a dose-dependent decrease in cell viability.fluorescence, which shows a dose- and time-dependent increase in HepG2 cells.The levels of DNA damage in HepG2 increased in all cells treated with an increasing dose of selenite

Keywords： NAC     N-acetylcysteine     DNA     fluorescence     relationship    

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Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation Article

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Engineering 2024, Volume 32, Issue 1,   Pages 58-69 doi: 10.1016/j.eng.2023.09.019

Abstract: nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkhead box protein A2(FOXA2) are key transcription factors that regulate a complex gene network in the liver, creating a regulatorygenes in HepG2 cells—a human liver cancer cell line.The effect is better seen as an overall change in the total HepG2 N-glycome, primarily due to–FOXA2 affecting glyco-genes and protein glycosylation in HepG2 cells.

Keywords： Hepatocyte nuclear factor 1 alpha (HNF1A)     Hepatocyte nuclear factor 4 alpha (HNF4A)     Forkhead box protein A2(FOXA2)     N-glycosylation     HepG2 cells    

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GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Frontiers of Medicine doi: 10.1007/s11684-023-1007-9

Abstract: Brain development requires a delicate balance between self-renewal and differentiation in neural stem cellsTen-eleven translocation 2 (TET2) modulates gene expression by the hydroxymethylation of 5-methylcytosineYet, the regulation of TET2 in the process of neuronal differentiation remains unknown.of the GID complex, including WDR26 and ARMC8, attenuated the ubiquitination and degradation of TET2,TET2 level increased in the brain of the Wdr26+/− mice.

Keywords： TET2     GID complex     neural stem cells     differentiation of neurons    

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Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study

Ranhua JIANG, Zhibo HAN, Guangsheng ZHUO, Xiaodan QU, Xue LI, Xin WANG, Yuankang SHAO, Shimin YANG, Zhong Chao HAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 94-100 doi: 10.1007/s11684-011-0116-z

Abstract:

Mesenchymal stem cells (MSC) have been used in clinical trials for severe diabetes, a chronic diseaseHere, the therapeutic effect of human placenta-derived MSC (PD-MSC) was studied in type 2 diabetes patientsglycemic control in order to evaluate the safety, efficacy and feasibility of PD-MSC treatment in type 2diabetes (T2D).Ten patients with T2D received three intravenous infusions of PDSC, with one month interval of infusion

Keywords： placenta stem cells     treatment of type 2 diabetes    

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Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladder

FAN Xiaodong, HAN Ruifa

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 377-380 doi: 10.1007/s11684-007-0073-8

Abstract: were stimulated by recombinant BCG and transformed into bacilli Calmette–Guerin activated killer (BAK) cells, and the effect of anticancer BAK cells was studied.Recombinant IFN--2b-BCG, wild-type BCG (wBCG), wild-type BCG and IFN--2b were coincubated with PBMCsBAK cells have the ability to kill bladder tumor cells, and the antitumor activity of effecter cellsThe result of LDH release assay showed that the antitumor activity of BAK cells stimulated by Recombinant

Keywords： Urology     powerful     2b-BCG     Tianjin institute     wild-type    

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SALL4 maintains self-renewal of porcine pluripotent stem cells through downregulation of OTX2

Ning WANG, Sile WANG, Yaxian WANG, Yuanxing CAI, Fan YANG, Huayan WANG

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 81-92 doi: 10.15302/J-FASE-2017180

Abstract: splicing variants, which are differentially expressed and has a key role in maintaining pluripotent stem cellsmolecular features and function of SALL4 have not been well elucidated in porcine induced pluripotent stem cellsOverexpression of SALL4A and SALL4B in PEF cells could significantly stimulated expression of endogenousConversely, OTX2 also negatively regulated SALL4 expression.observations indicate that a negative feedback regulatory mechanism may exist between SALL4 and OTX2,

Keywords： OTX2     pluripotency     pig     SALL4     transcription regulation    

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Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive

Frontiers of Medicine doi: 10.1007/s11684-023-0999-5

Abstract: Through bioinformatics predictions, we identified that GTF2I and FAT1 were downregulated in thyroid carcinomaFurther, Pearson’s correlation coefficient revealed a positive correlation between GTF2I expression andThe under-expression of GTF2I and FAT1 was validated in TC cell lines.Ectopically expressed GTF2I and FAT1 were found to augment malignant phenotypes of TC cells, EMT, andMSC-EVs could shuttle GTF2I into TPC-1 cells, where GTF2I inhibited TC malignant phenotypes, EMT, and

Keywords： thyroid carcinoma     mesenchymal stem cell     extracellular vesicle     GTF2I     FAT1     CDK4    

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Effect of bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involved

Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 225-228 doi: 10.1007/s11684-010-0003-z

Abstract: The aim of this paper is to study the effect of bradykinin (BK) on bradykinin-B2 receptor as well asthe possible involved signal transduction pathways in cultured rat aortic vascular smooth muscle cellsCells after 4–6 passages were used in the experiment.receptor in VSMC. (2) Apigenin, PD98059, Akt inhibitor, and LY294002 inhibited up-regulation of B2 receptorResults suggest that bradykinin can up-regulate the expression of B2 receptor in VSMCs.

Keywords： bradykinin     vascular smooth muscle cells     signal transduction pathways    

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Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial cells

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 781-795 doi: 10.1007/s11684-023-0986-x

Abstract: In vitro, the indirect coculture of macrophages derived from THP-1 and human corneal epithelial cells(HCECs) was used to discuss the interaction among cells.subsequent inflammation in macrophages upon the activation of the related gene and protein expression. 2-Deoxy-d-glucose (2-DG) could inhibit the glycolysis of HCECs and subsequently suppress the pyroptosisIn vivo, 2-DG showed potential efficacy in relieving DED activity and could significantly reduce

Keywords： dry eye disease     glycolytic reprogramming     pyroptosis     inflammation     2-DG    

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Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear haircells

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 637-650 doi: 10.1007/s11684-021-0864-3

Abstract: Results showed that apigenin significantly ameliorated the loss of hair cells and the accumulation ofFurther evidence suggested that the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathwayDisruption of the Nrf2 axis abolished the effects of apigenin on the alleviation of oxidative stressand subsequent apoptosis of hair cells.This study provided evidence of the protective effect of apigenin on cochlear hair cells and its underlying

Keywords： apigenin     aminoglycosides     ototoxicity     oxidative stress     Nrf2 signaling pathway    

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Review on Alkali Element Doping in Cu(In,Ga)Se2 Thin Films and Solar Cells

Yun Sun,Shuping Lin,Wei Li,Shiqing Cheng,Yunxiang Zhang,Yiming Liu,Wei Liu

Engineering 2017, Volume 3, Issue 4,   Pages 452-459 doi: 10.1016/J.ENG.2017.04.020

Abstract:

This paper reviews the development history of alkali element doping on Cu(In,Ga)Se2 (CIGS) solar cells and summarizes important achievements that have been made in this field.following issues: ① The delamination of CIGS thin films induced by Na incorporation facilitates CuInSe2cells

Keywords： Alkali elements     Cu(In     Ga)Se2     Thin-film solar cells     Post-deposition treatment    

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Orlistat induces ferroptosis-like cell death of lung cancer cells

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 922-932 doi: 10.1007/s11684-020-0804-7

Abstract: tested the anticancer activity of orlistat, an FDA-approved anti-obesity drug, in human and mouse cancer cellsfound that orlistat, as a single agent, inhibited the proliferation and viabilities of lung cancer cellsgenome-wide gene expression changes affected by orlistat treatment using RNA-seq and identified FAF2,

Keywords： orlistat     ferroptosis     FAF2     lung cancer    

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Enhancement of open circuit voltage in organic solar cells by doping a fluorescent red dye

Qing LI, Junsheng YU, Yue ZANG, Nana WANG, Yadong JIANG

Frontiers in Energy 2012, Volume 6, Issue 2,   Pages 179-183 doi: 10.1007/s11708-012-0177-y

Abstract: The open circuit voltage ( ) of small-molecule organic solar cells (OSCs) could be improved by dopingIn this paper, 4-(dicyanomethylene)-2-t-butyl-6-(1,1,7,7-tetramethyljulolidyl-9-enyl)-4H-pyran (DCJTB

Keywords： organic solar cells (OSCs)     open circuit voltage     fluorescent dye doping     4-(dicyanomethylene)-2-t-butyl    

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Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 186-195 doi: 10.1007/s11705-015-1540-4

Abstract: Increased expression levels of the RNA splicing regulator Transformer2 (abbreviated Tra2 ) have beenRecent work has revealed an intimate cross-regulation between Tra2 and the highly similar Tra2 proteinin human breast cancer cells, though these two proteins are encoded by separate genes created by a genewithin the checkpoint kinase 1 (CHK1) gene that plays a crucial function in the protection of cancer cellsBreast cancer cells depleted for Tra2 proteins have reduced CHK1 protein levels and accumulate DNA damage

Keywords： RNA splicing     gene expression     breast cancer     DNA damage     CHK1    

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Title Author Date Type Operation

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Journal Article

Relationship between reactive oxygen species and sodium-selenite-induced DNA damage in HepG2 cells

ZOU Yunfeng, NIU Piye, GONG Zhiyong, YANG Jin, YUAN Jing, WU Tangchun, CHEN Xuemin

Journal Article

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Journal Article

GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Journal Article

Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study

Ranhua JIANG, Zhibo HAN, Guangsheng ZHUO, Xiaodan QU, Xue LI, Xin WANG, Yuankang SHAO, Shimin YANG, Zhong Chao HAN

Journal Article

Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladder

FAN Xiaodong, HAN Ruifa

Journal Article

SALL4 maintains self-renewal of porcine pluripotent stem cells through downregulation of OTX2

Ning WANG, Sile WANG, Yaxian WANG, Yuanxing CAI, Fan YANG, Huayan WANG

Journal Article

Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive

Journal Article

Effect of bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involved

Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,

Journal Article

Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial cells

Journal Article

Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear haircells

Journal Article

Review on Alkali Element Doping in Cu(In,Ga)Se2 Thin Films and Solar Cells

Yun Sun,Shuping Lin,Wei Li,Shiqing Cheng,Yunxiang Zhang,Yiming Liu,Wei Liu

Journal Article

Orlistat induces ferroptosis-like cell death of lung cancer cells

Journal Article

Enhancement of open circuit voltage in organic solar cells by doping a fluorescent red dye

Qing LI, Junsheng YU, Yue ZANG, Nana WANG, Yadong JIANG

Journal Article

Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

Journal Article